Multiple osteochondromas: mutation update and description of the multiple osteochondromas mutation database (MOdb).

Abstract excerpt

Multiple osteochondromas (MO) is an autosomal dominant skeletal disease characterized by the formation of multiple cartilage-capped bone tumors growing outward from the metaphyses of long tubular bones. MO is genetically heterogeneous, and is associated with mutations in Exostosin-1 (EXT1) or Exostosin-2 (EXT2), both tumor-suppressor genes of the EXT gene family. All members of this multigene family encode...

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• Bone Tumor Diagnosis and Treatments
• Databases, Genetic
• Disease Models, Animal
• Exostoses, Multiple Hereditary
• EXT1 gene