Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In Vitro Validation of a CRISPR-Mediated CFTR Correction Strategy for Preclinical Translation in Pigs

17 May 2019

Abstract excerpt

Early efforts in cystic fibrosis (CF) gene therapy faced major challenges in delivery efficiency and sustained therapeutic gene expression. Recent advancements in engineered site-specific endonucleases such as clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 make permanent CF transmembrane conductance regulator ( CFTR ) gene correction possible. However, because of safety concerns of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Cystic Fibrosis Research Advances
Share to Energy Harvesting in Wireless Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31099266
DOI: 10.1089/hum.2019.074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Vitro Validation of a CRISPR-Mediated CFTR Correction Strategy for Preclinical Translation in PigsPMID 31099266Read ↗

A Dual-Locus-Targeting Strategy to Enhance CRISPR/Cas9-mediated CFTR Replacement via Helper-Dependent Adenoviral vector in porcine genomeSemantic proximity Read ↗

Potential of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapySemantic proximity Read ↗

Efficient Gene Delivery to Pig Airway Epithelia and Submucosal Glands Using Helper-Dependent Adenoviral VectorsSemantic proximity Read ↗

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.Semantic proximity Read ↗

Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus.Semantic proximity Read ↗

A Novel AAV-mediated Gene Delivery System Corrects CFTR Function in PigsSemantic proximity Read ↗

Gene therapy for cystic fibrosis: Challenges and prospectsSemantic proximity Read ↗

Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer.Semantic proximity Read ↗

Transducing Airway Basal Cells with a Helper-Dependent Adenoviral Vector for Lung Gene TherapySemantic proximity Read ↗

Development of a porcine model of cystic fibrosis.Semantic proximity Read ↗

Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs.Semantic proximity Read ↗

Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.