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Article

Multicellular gene network analysis identifies a macrophage-related gene signature predictive of therapeutic response and prognosis of gliomas

16 May 2019

Abstract excerpt

BACKGROUND: The tumor-associated microenvironment plays important roles in tumor progression and drug resistance. However, systematic investigations of macrophage-tumor cell interactions to identify novel macrophage-related gene signatures in gliomas for predicting patient prognoses and responses to targeted therapies are lacking. METHODS: We developed a multicellular gene network approach to investigating the...

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PMID: 31097021
DOI: 10.1186/s12967-019-1908-1

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