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Nucleoporin Nup155 is part of the p53 network in liver cancer

14 May 2019

Abstract excerpt

Cancer-relevant signalling pathways rely on bidirectional nucleocytoplasmic transport events through the nuclear pore complex (NPC). However, mechanisms by which individual NPC components (Nups) participate in the regulation of these pathways remain poorly understood. We discover by integrating large scale proteomics, polysome fractionation and a focused RNAi approach that Nup155 controls mRNA translation of p21...

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PMID: 31089132
DOI: 10.1038/s41467-019-10133-z

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