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Article

Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells

24 Apr 2019

Abstract excerpt

Stem Cell Antigen-1 (Sca-1/Ly6A) was the first identified member of the Lymphocyte antigen-6 (Ly6) gene family. Sca-1 serves as a marker of cancer stem cells and tissue-resident stem cells in mice. The Sca-1 gene is located on mouse chromosome 15. While a direct homologue of Sca-1 in humans is missing, human chromosome 8 - the syntenic region to mouse chromosome 15 - harbors several genes containing the...

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PMID: 31068932
DOI: 10.3389/fimmu.2019.00819

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