Article
Acute Myeloid Leukemia in a Patient With X-linked Severe Combined Immunodeficiency.
Journal of pediatric hematology/oncology - 1 Nov 2017
Shigemura Tomonari, Motobayashi Mitsuo, Matsuda Kazuyuki, Shimodaira Takahiro, Kurata Takashi, Kobayashi Norimoto, Agematsu Kazunaga, Nakazawa Yozo
Abstract excerpt
Severe combined immunodeficiency (SCID) is a defect in the differentiation and function of T cells. An increased malignancy risk, mainly lymphatic malignancy, has been described in patients with SCID. We report a patient with X-linked SCID who developed acute myeloid leukemia, derived from the recipient with somatic NRAS mutation 4 months after cord blood transplantation (CBT). Loss of heterozygosity phenomenon...
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