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Article

Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure.

Clinical epigenetics - 7 May 2019

Huang Yun, Ren Aiguo, Wang Linlin, Jin Lei, Lin Shanshan, Li Zhiwen, McDonald Jasmine A

Abstract excerpt

BACKGROUND: Epidemiological studies have found that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with increased risk for neural tube defects (NTDs). Aberrant DNA methylation, excessive apoptosis, and oxidative stress have been implied as the mechanism underlying the association between PAH exposure and NTDs, respectively. However, the role of DNA methylation aberration of apoptotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31064411
DOI: 10.1186/s13148-019-0673-6
PMCID: PMC6505285

Genes

CASP8
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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