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Article

MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes

3 May 2019

Abstract excerpt

Abnormal post-transcriptional modulations in inflammatory genes by microRNAs (miRNAs) play a crucial role in human disorders including arthritis. In this study, we determined the effect of hsa-miR-125b-5p on interleukin (IL)-1β induced inflammatory genes in human osteoarthritic (OA) chondrocytes. Bioinformatics algorithms showed 3'untranslated region (3'UTR) of TRAF6 mRNA (NM_004620.3) has perfectly matched...

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PMID: 31053727
DOI: 10.1038/s41598-019-42601-3

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