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Zebrafish mab21l2 mutants possess severe defects in optic cup morphogenesis, lens and cornea development

30 Apr 2019

Abstract excerpt

Abstract Background Mutations in MAB21L2 result in severe ocular defects including microphthalmia, anophthalmia, coloboma, microcornea, and cataracts. The molecular and cellular underpinnings of these defects are unknown, as is the normal cellular function of MAB21L2. Zebrafish mab21l2 au10 mutants possess ocular defects resembling those in humans with MAB21L2 mutations, providing an excellent model to...

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PMID: 31037784
DOI: 10.1002/dvdy.44

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