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Genome‐wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth

25 Apr 2019

Abstract excerpt

ABSTRACT Hepatocellular carcinoma (HCC) is a common and deadly cancer with limited treatment options. Through genome‐wide growth depletion screens using clustered regularly interspaced short palindromic repeats and expression profiling of primary HCC tumors, we identified 13 clinically relevant target genes with therapeutic potential. Subsequent functional annotation analysis revealed significant enrichment of...

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PMID: 31022357
DOI: 10.1096/fj.201802213rr

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