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Article

UV irradiation‐induced DNA hypomethylation around WNT1 gene: Implications for solar lentigines

25 Apr 2019

Abstract excerpt

Wnt/β-catenin signalling promotes melanogenesis in melanocytes and also induces melanocytogenesis from melanocyte stem cells (McSCs). Previous study reported that WNT1, a ligand which activates Wnt/β-catenin signalling pathway, was more highly expressed in the epidermis at SLs than in normal skin areas, suggesting that WNT1 causes hyperpigmentation. To elucidate the mechanism by which WNT1 expression is increased...

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PMID: 31020703
DOI: 10.1111/exd.13949

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