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Article

Rare variants in MYH15 modify amyotrophic lateral sclerosis risk.

Human molecular genetics - 15 Jul 2019

Kim Hyerim, Lim Junghwa, Bao Han, Jiao Bin, Canon Se Min, Epstein Michael P, Xu Keqin, Jiang Jie, Parameswaran Janani, Li Yingjie, Moberg Kenneth H, Landers John E, Fournier Christina, Allen Emily G, Glass Jonathan D, Wingo Thomas S, Jin Peng

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive muscular atrophy and respiratory failure. The G4C2 repeat expansion in the C9orf72 gene is the most prevalent genetic risk for ALS. Mutation carriers (C9ALS) display variability in phenotypes such as age-at-onset and duration, suggesting the existence of additional genetic factors. Here we introduce a three-step gene...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microfilament Proteins

Share to Myosin Heavy Chains

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Source

Open in PubMed Open full text

Identifiers

PMID: 30985904
DOI: 10.1093/hmg/ddz063
PMCID: PMC6606848

Genes

MYH15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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