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ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma

10 Aug 2022

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is labeled with high mortality and tolerance to chemotherapy. Sorafenib has been the first-line treatment option in HCC patients for past decades, while the therapeutic effect was limited in almost HCC patients. METHODS: In this study, we analyzed public omics data of HCC patients with different responses to Sorafenib treatment. To confirm the role of integrins A5 and B1...

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Share to Angiogenesis and VEGF in Cancer
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35946175
DOI: 10.1002/cam4.5110

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