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Article

Modelling human papillomavirus biology in oropharyngeal keratinocytes

8 Apr 2019

Abstract excerpt

Most human papillomavirus (HPV) positive head and neck cancers arise in the tonsil crypts; deep invaginations at the tonsil surface that are lined with reticulated epithelium infiltrated by immune cells. As in cervical HPV infections, HPV16 is the most prevalent high-risk type in the oropharyngeal cancers, and a genital-oral route of infection is most likely. However, the natural history of HPV-driven...

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PMID: 30955493
DOI: 10.1098/rstb.2018.0289

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