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Somatic mutation of DNAH genes implicated higher chemotherapy response rate in gastric adenocarcinoma patients

3 Apr 2019

Abstract excerpt

BACKGROUND: The dynein axonemal heavy chain (DNAH) family of genes encode the dynein axonemal heavy chain, which is involved in cell motility. Genomic variations of DNAH family members have been frequently reported in diverse kinds of malignant tumors. In this study, we analyzed the genomic database to evaluate the mutation status of DNAH genes in gastric adenocarcinoma and further identified the significance of...

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PMID: 30944005
DOI: 10.1186/s12967-019-1867-6

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