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Exploring the nexus between MYH9 and tumors: novel insights and new therapeutic opportunities

1 Aug 2024

Abstract excerpt

The myosin heavy chain 9 (MYH9) gene, located on human chromosome 22, encodes non-muscle myosin heavy chain IIA (NM IIA). This protein is essential to various cellular events, such as generating intracellular chemomechanical force and facilitating the movement of the actin cytoskeleton. Mutations associated with thrombocytopenia in autosomal dominant diseases first highlighted the significance of the MYH9 gene....

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PMID: 39149512
DOI: 10.3389/fcell.2024.1421763

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