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Article

Receptor tyrosine kinase amplified gastric cancer: Clinicopathologic characteristics and proposed screening algorithm.

Oncotarget - 1 Nov 2016

Park Cheol Keun, Park Ji Soo, Kim Hyo Song, Rha Sun Young, Hyung Woo Jin, Cheong Jae-Ho, Noh Sung Hoon, Lee Sang Kil, Lee Yong Chan, Huh Yong-Min, Kim Hyunki

Abstract excerpt

Although targeted therapy for receptor tyrosine kinases (RTKs) of advanced gastric cancers (AGCs) has been in the spotlight, guidelines for the identification of RTK-amplified gastric cancers (RA-GCs) have not been established. In this study, we investigate clinicopathologic characteristics of RA-GCs and propose a screening algorithm for their identification. We performed immunohistochemistry (IHC) for MLH1,...

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Source

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Identifiers

PMID: 27765925
DOI: 10.18632/oncotarget.12291
PMCID: PMC5342148

Genes

EGFR
MET
MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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