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Article

Defensin alpha 6 (DEFA6) is a prognostic marker in colorectal cancer

26 Mar 2019

Abstract excerpt

Defensin alpha 6 (DEFA6) is a member of the alpha defensin family of microbicidal and cytotoxic peptides that defend against bacteria and viruses. Here, we provide a novel function of DEFA6 in tumorigenesis of colorectal cancer (CRC) in vitro and in vivo. Specifically, DEFA6 is highly expressed in both CRC cancer cell lines as well as patient-derived samples at the level of RNA and protein. By shRNA-mediated loss...

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PMID: 30932884
DOI: 10.3233/cbm-182221

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