Article
Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients.
BMC cancer - 27 Oct 2010
Radeva Mariya Y, Jahns Franziska, Wilhelm Anne, Glei Michael, Settmacher Utz, Greulich Karl Otto, Mothes Henning
Abstract excerpt
BACKGROUND: It is known that alpha-defensin expression is enhanced in colon cancer. However, the expression of human alpha defensin 6 (DEFA 6) in earlier stages, such as adenoma, has so far not yet been studied in a patient resolved manner. METHODS: By using quantitative Real Time-PCR, the gene expression pattern of DEFA 1-3 and DEFA 6 was analyzed in tissue of different stages of carcinogenesis, derived from...
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