Article
In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth-a clinically relevant distinction.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2019
Moore David Allan, Sereno Marco, Das Madhumita, Baena Acevedo Juvenal Dario, Sinnadurai Samantha, Smith Claire, McSweeney Abi, Su Xiaoyu, Officer Leah, Jones Carolyn, Dudek Kate, Guttery David, Taniere Phillipe, Spriggs Ruth V, Le Quesne John
Abstract excerpt
The switch from in situ to invasive tumor growth represents a crucial stage in the evolution of lung adenocarcinoma. However, the biological understanding of this shift is limited, and 'Noguchi Type C' tumors, being early lung adenocarcinomas with mixed in situ and invasive growth, represent those that are highly valuable in advancing our understanding of this process. All Noguchi Type C adenocarcinomas (n = 110)...
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