Article
Structural variation in the gut microbiome associates with host health.
Nature - 1 Apr 2019
Zeevi David, Korem Tal, Godneva Anastasia, Bar Noam, Kurilshikov Alexander, Lotan-Pompan Maya, Weinberger Adina, Fu Jingyuan, Wijmenga Cisca, Zhernakova Alexandra, Segal Eran
Abstract excerpt
Differences in the presence of even a few genes between otherwise identical bacterial strains may result in critical phenotypic differences. Here we systematically identify microbial genomic structural variants (SVs) and find them to be prevalent in the human gut microbiome across phyla and to replicate in different cohorts. SVs are enriched for CRISPR-associated and antibiotic-producing functions and depleted...
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