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PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients

28 Mar 2019

Abstract excerpt

Dyslipidemia and altered iron metabolism are typical features of nonalcoholic fatty liver disease (NAFLD). Proprotein convertase subtilisin/kexin type 7 ( PCSK7 ) gene variation has been associated with circulating lipids and liver damage during iron overload. The aim of this study was to examine the impact of the PCSK7 rs236918 variant on NAFLD-related traits in 1,801 individuals from the Liver Biopsy Cohort...

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PMID: 30918065
DOI: 10.1194/jlr.p090449

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