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Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs

25 Jan 2019

Abstract excerpt

Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) infection of fibroblasts. Based upon the results of this study, we treated CHIKV-infected cells with kinase inhibitors...

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PMID: 30917980
DOI: 10.1128/aac.02325-18

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