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Article

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis

27 Mar 2019

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. Our study was aimed to uncover new connections within the ALS network through a bioinformatic approach, by which we identified C13orf18, recently named Pacer, as a new component of the...

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PMID: 30917850
DOI: 10.1186/s13024-019-0313-9

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