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Article

Genistein treatment duration effects biomarkers of cell motility in human prostate

27 Mar 2019

Abstract excerpt

BACKGROUND: Long term dietary consumption of genistein by Chinese men is associated with decreased PCa metastasis and mortality. Short term treatment of US men with prostate cancer (PCa) with genistein decreases MMP-2 in prostate tissue. MEK4 regulates MMP-2 expression, drives PCa metastasis, and genistein inhibits MEK4, decreases MMP-2 expression and dietary dosing inhibits human PCa metastasis in mice. This...

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PMID: 30917169
DOI: 10.1371/journal.pone.0214078

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