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Article

Anti-tumor immunity induced by ectopic expression of viral antigens is transient and limited by immune escape

6 Feb 2019

Abstract excerpt

Immunotherapeutic treatments in head and neck cancer clinical trials include cancer vaccines targeting foreign viral antigens or mutational neoantigens derived from cancer-expressed proteins. Anti-tumor immune responses place cancer cells under selective pressure to lose or downregulate target antigens; therefore, vaccination against virus- or host- “driver” oncogenes are proposed as a strategy to overcome immune...

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PMID: 30906661
DOI: 10.1080/2162402x.2019.1568809

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