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Article

Longitudinal adaptive optics fluorescence microscopy reveals cellular mosaicism in patients

21 Mar 2019

Abstract excerpt

The heterogeneity of individual cells in a tissue has been well characterized, largely using ex vivo approaches that do not permit longitudinal assessments of the same tissue over long periods of time. We demonstrate a potentially novel application of adaptive optics fluorescence microscopy to visualize and track the in situ mosaicism of retinal pigment epithelial (RPE) cells directly in the human eye. After a...

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PMID: 30895942
DOI: 10.1172/jci.insight.124904

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