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Article

Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation

19 Mar 2019

Abstract excerpt

mRNA in postmortem brain samples (Brodmann area 9 and 40) from ASD patients was higher than that of controls. Treatment with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea (TPPU), a potent sEH inhibitor, in juvenile offspring from prenatal day (P) 28 to P56 could prevent cognitive deficits and loss of parvalbumin (PV) immunoreactivity in the medial PFC of adult offspring after MIA. In addition, dosing...

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PMID: 30890645
DOI: 10.1073/pnas.1819234116

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