Preeclampsia promotes autism in offspring via maternal inflammation and fetal NFκB signaling

Abstract excerpt

Preeclampsia (PE) is a risk factor for autism spectrum disorder (ASD) in offspring. However, the exact mechanisms underlying the impact of PE on progeny ASD are not fully understood, which hinders the development of effective therapeutic approaches. This study shows the offspring born to a PE mouse model treated by N ω -nitro-L-arginine methyl ester (L-NAME) exhibit ASD-like phenotypes, including neurodevelopment...

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