Contribution of YjbIH to Virulence Factor Expression and Host Colonization in Staphylococcus aureus

Abstract excerpt

To persist within the host and cause disease, Staphylococcus aureus relies on its ability to precisely fine-tune virulence factor expression in response to rapidly changing environments. During an unbiased transposon mutant screen, we observed that disruption of a two-gene operon, yjbIH , resulted in decreased levels of pigmentation and aureolysin (Aur) activity relative to the wild-type strain.

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