Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Over-Expression of CHD4 Is an Independent Biomarker of Poor Prognosis in Patients with Rectal Cancers Receiving Concurrent Chemoradiotherapy

21 Aug 2019

Abstract excerpt

Neoadjuvant concurrent chemoradiotherapy (CCRT), followed by radical proctectomy, is the standard treatment for locally advanced rectal cancer. However, a poor response and therapeutic resistance continue to occur despite this treatment. In this study, we analyzed the microarray datasets (GSE68204) of rectal cancer from the Gene Expression Omnibus database, and identified CHD4 as one of the most significantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal and Anal Carcinomas
Share to Colorectal Cancer Surgical Treatments
Share to Gastric Cancer Management and Outcomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31438571
DOI: 10.3390/ijms20174087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Over-Expression of CHD4 Is an Independent Biomarker of Poor Prognosis in Patients with Rectal Cancers Receiving Concurrent ChemoradiotherapyPMID 31438571Read ↗

Genome-wide RNAi Screening Identifies RFC4 as a Factor That Mediates Radioresistance in Colorectal Cancer by Facilitating Nonhomologous End Joining RepairSemantic proximity Read ↗

CHD4 regulates the DNA damage response and RAD51 expression in glioblastomaSemantic proximity Read ↗

Pan-Cancer Multi-Omics Analysis Uncovers CHD4 Driving Tumor Progression via Epigenetic Regulation of Genomic Stability and the Immune MicroenvironmentSemantic proximity Read ↗

CHD4/NuRD complex regulates complement gene expression and correlates with CD8 T cell infiltration in human hepatocellular carcinomaSemantic proximity Read ↗

HDGF Knockout Suppresses Colorectal Cancer Progression and Drug Resistance by Modulating the DNA Damage ResponseSemantic proximity Read ↗

LncRNA CEBPA-DT promotes liver cancer metastasis through DDR2/β-catenin activation via interacting with hnRNPCSemantic proximity Read ↗

LncRNAs Signature Associated with Chemoradiotherapy Response and Prognosis in Locally Advanced Rectal CancerSemantic proximity Read ↗

Long non-coding RNA C20orf56 as predictor for response to neoadjuvant CCRT and survival rates of rectal cancersSemantic proximity Read ↗

Downregulation of chromatin remodeling factor CHD5 is associated with a poor prognosis in human gliomaSemantic proximity Read ↗

Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4.Semantic proximity Read ↗

Defeating EpCAM+ liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinomaSemantic proximity Read ↗

NOTCH4 regulates colorectal cancer proliferation, invasiveness, and determines clinical outcome of patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.