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Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3

8 Mar 2019

Abstract excerpt

Radiation therapy is used in ~50% of cancer patients to reduce the risk of recurrence and in some cases improve survival. Despite these benefits, doses can be limited by toxicity in multiple organs, including the heart. The underlying causes and biomarkers of radiation-induced cardiotoxicity are currently unknown, prompting the need for experimental models with inherent differences in sensitivity and resistance...

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PMID: 30848680
DOI: 10.1152/ajpheart.00482.2018

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