Article
Limited available evidence supports theoretical predictions of reduced vaccine efficacy at higher exposure dose
1 Mar 2019
Abstract excerpt
Understanding the causes of vaccine failure is important for predicting disease dynamics in vaccinated populations and planning disease interventions. Pathogen exposure dose and heterogeneity in host susceptibility have both been implicated as important factors that may reduce overall vaccine efficacy and cause vaccine failure. Here, we explore the effect of pathogen dose and heterogeneity in host susceptibility...
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