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Article

Fibroblast Growth Factor 2 Enhances Zika Virus Infection in Human Fetal Brain

13 Feb 2019

Abstract excerpt

Zika virus (ZIKV) is an emerging pathogen that can cause microcephaly and other neurological defects in developing fetuses. The cellular response to ZIKV in the fetal brain is not well understood. Here, we show that ZIKV infection of human fetal astrocytes (HFAs), the most abundant cell type in the brain, results in elevated expression and secretion of fibroblast growth factor 2 (FGF2). This cytokine was shown to...

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PMID: 30799482
DOI: 10.1093/infdis/jiz073

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