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Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia

19 Feb 2019

Abstract excerpt

Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation is detectable in both brain and blood. We examined free mono-ubiquitin, ubiquitinated proteins, catalytic ubiquitination, and proteasome activities in frozen postmortem OFC tissue from 76 (38 schizophrenia, 38 control) matched individuals, as well as erythrocytes from 181 living...

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PMID: 30783160
DOI: 10.1038/s41598-019-38490-1

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