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Article

Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway

30 Jan 2019

Abstract excerpt

Background Chondrosarcomas are malignant cartilage-producing tumors showing mutations and changes in gene expression in metabolism related genes. In this study, we aimed to explore the metabolome and identify targetable metabolic vulnerabilities in chondrosarcoma. Methods A custom-designed metabolic compound screen containing 39 compounds targeting different metabolic pathways was performed in chondrosarcoma cell...

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Share to Bone Tumor Diagnosis and Treatments
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PMID: 30766792
DOI: 10.1016/j.jbo.2019.100222

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