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Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

24 Jun 2020

Abstract excerpt

BACKGROUND: Cancer stem cell (CSC) is identified in osteosarcoma (OS) and considered resistant to chemotherapeutic agents. However, the mechanism of osteosarcoma stem cell (OSC) resistant to chemotherapy remains debatable and vague, and the metabolomics feature of OSC is not clarified. MATERIALS AND METHODS: OSC was isolated by using sphere forming assay and identified. Untargeted LC-MS/MS analysis was performed...

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PMID: 32587477
DOI: 10.1186/s12935-020-01356-y

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