Legionella pneumophila translocated translation inhibitors are required for bacterial-induced host cell cycle arrest

Abstract excerpt

Significance The host cell cycle regulatory proteins control Legionella pneumophila growth. In particular, bacterial replication is depressed in S phase. This indicates that bacterial control of the host cell cycle can limit exposure of the pathogen to antimicrobial events that are cycle-specific. Here we uncovered bacterial factors that induce host cell cycle arrest by inhibiting host protein synthesis and...

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