MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

Abstract excerpt

Significance Currently, there is no effective targeted therapy for oncogenic KRAS -driven cancer. We set out to identify RAS effector and stress response genes that critically support KRAS addiction, and therefore could serve as potential targets for KRAS mutant cancer. Using a combinatorial siRNA platform, we systematically interrogated the patterns of oncoeffector dependency in KRAS mutant and WT colorectal and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Endoplasmic Reticulum Stress and Disease
• Share to Ubiquitin and proteasome pathways