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Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function

29 Jan 2019

Abstract excerpt

BACKGROUND: Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors. Human Leukocyte Antigen null cells are used in vitro to stimulate natural killer cell activation through missing-self mechanisms. On the other hand, CEM.NKr.CCR5 cells are used to stimulate natural killer cells in an...

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PMID: 30696399
DOI: 10.1186/s12865-018-0272-x

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