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Role of tumor-associated neutrophils in regulation of tumor growth in lung cancer development: A mathematical model

28 Jan 2019

Abstract excerpt

Neutrophils display rapid and potent innate immune responses in various diseases. Tumor-associated neutrophils (TANs) however either induce or overcome immunosuppressive functions of the tumor microenvironment through complex tumor-stroma crosstalk. We developed a mathematical model to address the question of how phenotypic alterations between tumor suppressive N1 TANS, and tumor promoting N2 TANs affect...

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PMID: 30689655
DOI: 10.1371/journal.pone.0211041

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