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Article

Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor

30 Nov 2018

Abstract excerpt

Adoptive transfer of T cells expressing a chimeric antigen receptor (CAR) is a promising cell-based anticancer therapy. Although clinical studies of this approach show therapeutic efficacy, additional genetic modification is necessary to enhance the efficacy and safety of CAR-T cells. For example, production of an antitumor cytokine from CAR-T cells can potentially enhance their tumor-killing activity, but there...

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PMID: 30662937
DOI: 10.1016/j.omto.2018.11.003

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