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Transport of the Ruthenium Complex [Ru(GA)(dppe)2]PF6into Triple-Negative Breast Cancer Cells Is Facilitated by Transferrin Receptors

11 Jan 2019

Abstract excerpt

The triple-negative breast cancer subtype (TNBC) is highly aggressive and metastatic and corresponds to 15–20% of diagnosed cases. TNBC treatment is hampered, because these cells usually do not respond to hormonal therapy, and they develop resistance to chemotherapeutic drugs. On the other hand, the severe side effects of cisplatin represent an obstacle for its clinical use. Ruthenium (Ru)-based complexes have...

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PMID: 30633527
DOI: 10.1021/acs.molpharmaceut.8b01154

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