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Circulating Tumor Cells: Come Together, Right Now, Over Metastasis

1 Jan 2019

Abstract excerpt

Abstract Summary: Circulating tumor cells (CTC) are the source of metastases, but only an infinitesimal fraction of them eventually succeed in colonizing a distant organ. New results show that CD44-dependent aggregation in the circulation provides CTCs with cancer stem cell–like characteristics, suggesting an explanation for the low metastatic efficiency of CTCs, but also avenues for therapeutic intervention. See...

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PMID: 30626605
DOI: 10.1158/2159-8290.cd-18-1285

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