Article
[Mutations of resistance to 6-thioguanine following roentgen irradiation and subsequent treatment with cytosine arabinoside combined with hydroxyurea in Chinese hamster cells in the G1 phase].
Radiobiologiia - 1 Jan 2000
Elisova T V, Feoktistova T P, Stavrakova N M
Abstract excerpt
A study was made of the effect of two-hour treatment of Chinese hamster cells with cytosine arabinoside (AraC) combined with hydroxyurea (HU) at the G1 phase of the cell cycle on lethal and mutagenic effects of X-radiation (50 to 400 cGy). The inhibitors were shown to increase a spontaneous mutation level of the resistance to 6-thioguanine: this increase augmented by 3 times as the time the treatment increased...
Topics
- Animals
- Cell Line
- Cell Survival
- Cricetinae
- Cricetulus
- Cytarabine
- Drug Resistance
- Hydroxyurea
- In Vitro Techniques
- Interphase
- Mutation