The R132H mutation in IDH 1 promotes the recruitment of NK cells through CX 3 CL 1/ CX 3 CR 1 chemotaxis and is correlated with a better prognosis in gliomas

Abstract excerpt

Mutations in the isocitrate dehydrogenase (IDH) 1 gene, especially the R132H mutation, have been reported to be associated with a better prognosis in glioma patients. However, the underlying molecular mechanisms are not yet well understood. Many factors may contribute to differences in the survival of IDH1 wild-type and IDH1 mutant glioma patients, in which immune components play a potentially important role. In...

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