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Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks

1 Oct 2024

Abstract excerpt

Sex-specific differences in lifespan and ageing are observed in various species. In humans, women generally live longer but are frailer and suffer from different age-related diseases compared to men. The hallmarks of ageing, such as genomic instability, telomere attrition or loss of proteostasis, exhibit sex-specific patterns. Sex chromosomes and sex hormones, as well as the epigenetic regulation of the inactive...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genetics, Aging, and Longevity in Model Organisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39471841
DOI: 10.1098/rsob.240177

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