Article
Selective Survival of Embryos Can Explain DNA Methylation Signatures of Adverse Prenatal Environments
1 Dec 2018
Abstract excerpt
An adverse intrauterine environment is associated with long-term physiological changes in offspring. These are believed to be mediated by epigenomic marks, including DNA methylation (DNAm). Changes in DNAm are often interpreted as damage or plastic responses of the embryo. Here, we propose that stochastic DNAm variation, generated during remodeling of the epigenome after fertilization, contributes to DNAm...
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