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Article

Improving the calling of non-invasive prenatal testing on 13-/18-/21-trisomy by support vector machine discrimination

5 Dec 2018

Abstract excerpt

With the advance of next-generation sequencing (NGS) technologies, non-invasive prenatal testing (NIPT) has been developed and employed in fetal aneuploidy screening on 13-/18-/21-trisomies through detecting cell-free fetal DNA (cffDNA) in maternal blood. Although Z-test is widely used in NIPT NGS data analysis, there is still necessity to improve its accuracy for reducing a) false negatives and false positives,...

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Share to Fetal and Pediatric Neurological Disorders
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PMID: 30517156
DOI: 10.1371/journal.pone.0207840

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