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Genetic Analysis of NDT80 Family Transcription Factors in Candida albicans Using New CRISPR-Cas9 Approaches

20 Nov 2018

Abstract excerpt

Transcription factors play key roles in regulating virulence of the human fungal pathogen C. albicans . In addition to regulating the expression of virulence factors, they also control the ability of C. albicans to switch to filamentous hyphal growth, which facilitates biofilm formation on medical devices and invasion into tissues. We therefore used new CRISPR/Cas9 methods to examine the effects of deleting three...

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PMID: 30463924
DOI: 10.1128/msphere.00545-18

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